The Texas KidsCanSeq Study is part of the Clinical Sequencing Evidence-Generating Research (CSER) consortium funded by the NIH National Human Genome Research Institute. The goal of the study is to integrate genomic sequence information into the care of childhood cancer patients with high-risk solid tumors and brain tumors. In conjunction with Texas Children's Cancer Center and BCM's Whole Genome Laboratory, KidsCanSeq assesses the utility of exome sequence (ES) testing compared to more targeted methods in pediatric cancer patients.